Specificity of the immune response to a modified group B meningococcal polysaccharide conjugate vaccine.

نویسندگان

  • Samuel Moore
  • Esmé K Farley
  • Peter C Fusco
  • Francis Michon
چکیده

Antibodies to a modified group B meningococcal polysaccharide vaccine were examined for antigenic and functional specificities. Bactericidal determinants were investigated by using immunoaffinity columns and competitive inhibition of bactericidal activity in an in vitro killing assay. We conclude that nearly all of the vaccine-induced bactericidal activity is specific for the native polysaccharide.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 14 1  شماره 

صفحات  -

تاریخ انتشار 2007